Invasive species and infectious diseases are two of the world’s greatest ecological challenges. Invasions and epidemics are similar in many ways, including the spread of organisms into novel habitats (or hosts) and negative impacts on the populations of other species. While the conceptual overlap between invasion biology and disease ecology is relatively clear, their combined effects on ecological communities, and how they affect each other, are not well understood. Specifically, invasion biology has focused on the role of pathogens during initial invasion stages (i.e., enemy release and biotic resistance) and management (i.e., biological control). However, increasing evidence suggests that invaders accumulate pathogens over time. Many of the accumulated pathogens that have been studied are generalists, infecting native species in addition to invaders. Therefore, the processes that structure the pathogen communities associated with invasive species can have important implications for ecological communities. The impacts of invader-associated pathogen communities on invaders and co-occurring species can be difficult to predict due to the complex factors that affect host-pathogen interactions (e.g., evolutionary history, host community composition, the microbiome). In this symposium, speakers will present novel empirical studies on a range of systems in which invasion biology and disease ecology intersect. They will explore processes structuring the formation and impact of pathogen communities in invaded systems. The presentations and discussion will highlight long-term effects of invader-pathogen interactions, research needs, and opportunities for advances in data science to address these gaps.