Though we increasingly recognize strong links between environmental change and emerging human infectious disease threats, actionable solutions to reverse socio-ecological degradation and create win-win outcomes for people and nature are not well documented. Even where hypothetical solutions exist, objective scientific evaluation is lacking and a doom-and-gloom sentiment overwhelms the literature. To map a new way forward in cross-disciplinary research, this session will highlight a solutions-oriented approach based on "ecological levers for health,” actionable ecological/environmental interventions that reduce human infectious disease. Speakers will first outline new modeling work that describes how and why ecological levers can effectively complement or even replace classical medical and/or public health interventions to reduce human infectious disease burdens. Then we will hear about the success stories and challenges experienced by researchers and practitioners who have been implementing ecological levers for health in the field. For example, speakers will discuss how species restoration, reduced agrochemical pollution, and/or better dam engineering can effectively control waterborne infections like human schistosomiasis and how forest conservation can prevent arbovirus infection and/or diarrheal disease in humans. Finally, after diving into the details in these best-known case studies, speakers will synthesize what we’ve learned regarding viable ecological levers for health and suggest a future framework to develop and test new ecological interventions that simultaneously improve human health and safeguard the sustainability and functioning of ecosystems.