This symposium aims to discuss vector-borne disease ecology from multiple scales and how trans-disciplinary teamwork across these scales, as well as from outside the field altogether, can advance the field of study. A myriad of interactions among the virus, vector(s), host(s), and environment make up a complex disease system, and the symposium speakers will provide perspectives on how their scales and interactions of interest fit into that system as well as where they see potential for trans-disciplinary collaborations. The speakers are from a variety of subdisciplines and scales of interest (from virology on the micro scale to geography on the continental scale) and stages in career (from doctoral candidate to professor). The goal of the symposium is to bridge and augment the different subdisciplines along the virology-ecology spectrum by highlighting how collaborative teams can work (or have worked) together, how novel computational methods can be utilized, and how decision-making can be integrated with models.