This special session provides a regional perspective of Living Cultures and Local Ecology inviting indigenous/tribal peoples as historically underrepresented groups to address the ESA annual conference theme of “Extreme events, ecosystem resilience and human well-being.” Tribal representatives from the region, will share their cultural history, uses of ecosystems, habitats and resources. Examples will be provided of the challenges and opportunities that face indigenous communities of the southern United States in working with agencies, non-governmental organizations, tribes, academics, and industries to address ecological issues of cultural significance. This session offers an indigenous perspective for ecologists to explore and learn of the richer connections American Indians foster with integrating social and natural sciences to confront environmental change.