Results/Conclusions: The analysis identifies where potential concerns and opportunities arise associated with the different biomass supply simulations. For example, the primary type of LUC associated with supply scenarios involves changes in agricultural land management practices: the area managed as perennial cover in 2040 is 10 million hectares greater under base case biomass supply simulations than under business as usual. Additional changes occur to improve management through fencing and rotation on about 15 million hectares of pasture under biomass supply simulations. This study puts these changes into the context of the overall US agricultural landscape. Potential ecological implications of exotic species and displacing diverse unimproved pasture with monoculture crops are also discussed. Sensitivities and uncertainties associated with the analysis are reviewed including the important role of how parameters for the reference case (business is usual) are defined. Because biomass markets can interact with drivers of LUC in different ways, the potential effects on global deforestation and food security are described. The analysis illustrates how inconsistent use of terms and parameters can lead to widely divergent results when estimating LUC. We conclude with recommendations describing science-based approaches to address the LUC analysis challenge. For more information including research team members, see https://bioenergykdf.net/billionton2016/overview